Nutri-Supreme Research Kosher Ultimate Calm Description:

• Ultimate Calm – Advanced Mood, Focus & Sleep Support

NutriSupreme’s completely reformulated Ultimate Calm is a radically advanced, all-in-one practitioner-grade complex engineered to promote profound relaxation, emotional balance, and restorative sleep. Upgraded from the ground up with clinically researched Mediterranean Saffron, industry-leading Phytosome® technology, and highly bioavailable branded botanicals, this powerful matrix delivers unparalleled central nervous system support for patients facing daily stress, cognitive fatigue, and restless nights.

Key Benefits

• Promotes profound calmness and relaxation without causing unwanted daytime drowsiness


• Supports robust emotional balance and positive mood through targeted neurotransmitter precursors


• Enhances cognitive focus and mental resilience during periods of high stress


• Promotes quality, restorative sleep architecture and eases nighttime restlessness


• Delivers superior bioavailability and fast-acting results via advanced botanical Phytosome® delivery

Detailed Educational Overview

Mechanisms of Action The new Ultimate Calm operates across multiple central nervous system pathways to deliver comprehensive support. It actively modulates GABAergic activity (via Fermented GABA, Passion Flower, Valerian Root, and Relissa® Lemon Balm), supports robust serotonin synthesis (via 5-HTP, Saffron, and biologically active Biofolate®), and regulates the HPA axis to blunt the physiological impact of cortisol (via Sensoril® Ashwagandha).

Bioavailability and Absorption Advantages A key differentiator in this ground-up reformulation is the integration of next-generation delivery systems. We replaced standard lemon balm with Relissa® Lemon Balm Phytosome®, which utilizes a specialized lipid-based matrix to dramatically amplify the cellular absorption of its calming compounds. Additionally, the formula features Aquamin Mg™, a highly bioavailable marine-derived magnesium matrix, ensuring optimal systemic uptake.

Ingredient Synergy This formula represents the pinnacle of synergistic formulation. By pairing direct neurotransmitter precursors (like 5-HTP) with their essential active cofactors (Biofolate®) and botanical modulators (Saffron), the ingredients work in tandem to safely elevate mood and promote tranquility. The clinical efficacy of Saffron—which has shown remarkable results in clinical trials when compared to conventional cognitive and mood medications—perfectly complements the adaptogenic, stress-mediating power of Sensoril® Ashwagandha.

Use Cases and Applications Ultimate Calm is designed as a foundational, all-in-one protocol for patients requiring heavy-hitting, natural support for an overactive mind, high stress levels, mood fluctuations, or difficulty initiating and maintaining sleep. Its flexible dosing allows it to be used during the day for focus and resilience, or at night for deep, restorative rest.

Ingredient Breakdown

• Mediterranean Saffron Extract (2% safranal) (30 mg) — Function + Benefit: Modulates neurotransmitter balance; backed by robust clinical trials to powerfully promote emotional wellbeing, resilience, and a positive mood.


• Relissa® Lemon Balm Phytosome® (200 mg) — Function + Benefit: Advanced lipid-bound botanical; significantly enhances calmness, eases nervous tension, and supports cognitive function with vastly superior bioavailability compared to standard extracts.


• Sensoril® Ashwagandha (10% withanolide glycosides) (250 mg) — Function + Benefit: Premier clinically validated adaptogen; aggressively targets stress, regulates cortisol levels, and supports mental focus.


• 5-HTP (from Griffonia simplicifolia seed) (150 mg) — Function + Benefit: Direct precursor to serotonin; readily crosses the blood-brain barrier to safely support healthy serotonin and melatonin levels for optimal mood and sleep architecture.


• Biofolate® (L-5-methyltetrahydrofolate calcium) (1 mg / 1,700 mcg DFE) — Function + Benefit: Biologically active folate; serves as a crucial cofactor to drive optimal neurotransmitter synthesis and overall brain health.


• Aquamin Mg™ (100 mg) — Function + Benefit: Highly bioavailable marine magnesium; supports deep neuromuscular relaxation and essential enzymatic functions.


• Passion Flower Extract (4% vitexin) (400 mg) — Function + Benefit: Potent GABA synergist; promotes relaxation and helps quiet an overactive mind to ease sleep onset.


• L-Theanine (200 mg) — Function + Benefit: Alpha-wave promoting amino acid; induces a state of "alert relaxation," supporting focus and attention without sedation.


• Fermented GABA (200 mg) & Valerian Root Extract (0.8% valerenic acids) (100 mg) — Function + Benefit: Inhibitory neurotransmitter and botanical synergist; works harmoniously to calm the central nervous system and promote restorative sleep.

Serving Size 3 Capsules  Servings Per Container 30 Amount Per Serving   % DV Folate (as L-5-methyltetrahydrofolate calcium) (Biofolate)   1 mg (1700 mcg DFE)   425% Magnesium (from Aquamin Mg)   100 mg   24% L-Thenaine   200 mg   ** Ashwaganda Extract (Sensoril)(standardized to 10% withanolides glycosides)   400 mg   ** Lemon Balm Phytosome (Relissa)   200 mg   ** Passionflower Extract (standardized to 4% vitexin)   400 mg   * Valerian Root Extract (standardized to 0.8% valerian acids)   100 mg   ** Fermented GABA (gamma-aminobutyric acid)   200 mg   ** 5-HTP (from Griffonia simplicifolia seed)   150 mg   ** Mediterranean SAffron Extract (Standardized to 2% Safranal)   30 mg   ** **Daily Value (DV) not established

Other Ingredients:

Vegetable Capsule, Vegetable Cellulose, Vegetable Stearate and Silica.

Food Sensitivity:

This product contains no wheat, dairy, eggs, artificial flavorings, preservatives or colorings

Warning: 

If you are pregnant, nursing, taking any medications or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Store tightly closed in a cool, dry place.
Keep out of reach of children.
Tamper resistant.
Use only if safety seal is intact.

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Nutri-Supreme Research Kosher Ultimate Calm Suggested Use:

As a dietary supplement for adults, take three (3) capsules daily.
Timing: It may be taken in divided doses, preferably with a meal, or as directed by your healthcare practitioner.
To support daytime stress and focus, divide the dose throughout the day. For sleep support, take the full serving 30–60 minutes before bedtime.