Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.
This drug should not be used with the following medications because very serious interactions may occur: apomorphine, fluvoxamine.
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting alosetron.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anticholinergics/antispasmodics (e.g., atropine, dicyclomine), antidiarrheals (e.g., kaolin-pectin, loperamide), hydralazine, isoniazid, narcotics (e.g., codeine, diphenoxylate), procainamide.
Other medications can affect the removal of alosetron from your body, which may affect how alosetron works. Examples include cimetidine, quinolone antibiotics such as ciprofloxacin, among others.
Constipation can be a serious side effect of this medication. Discuss with your doctor or pharmacist before using any medications that may slow down the gut. Check the labels on all your medicines (e.g., allergy, cough-and-cold, sleep products) because they may contain ingredients that can cause constipation. Ask your pharmacist about the safe use of those products.
The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.