Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
This drug should not be used with the following medications because a very serious interaction may occur: cancer chemotherapy, ketorolac.
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting probenecid.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: dyphylline, methotrexate, NSAIDs (e.g., ibuprofen, indomethacin, naproxen), pyrazinamide, salicylates (e.g., high-dose aspirin), certain "water pills" (e.g., furosemide, thiazide diuretics), zidovudine, certain drugs removed from your body by the kidneys (e.g., dapsone, doripenem, ganciclovir, heparin, certain antibiotics such as cephalosporins/penicillins/beta lactams/nitrofurantoin).
Aspirin and other salicylate-type medicines can prevent probenecid from being fully effective. Many nonprescription products contain aspirin. Consult your pharmacist before using nonprescription medicines if you are uncertain whether they contain aspirin. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Ask your doctor or pharmacist for more details.
Alcohol can decrease this drug's effectiveness. Limit alcohol while taking this medication.
This medication may interfere with certain laboratory tests (including urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.