As of the last update, we have found no reported interactions between this medicine and specific foods, supplements, or other compounds. It is possible that unknown interactions exist. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects; refer to the Uses and Precautions tabs or to the manufacturers’ package information for details as this is not covered in Nutrient Interactions. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: cancer chemotherapy, ketorolac, dyphylline, methotrexate, NSAIDs (e.g., ibuprofen, indomethacin, naproxen), pyrazinamide, salicylates (e.g., high-dose aspirin), zidovudine, certain drugs removed from your body by the kidneys (e.g., dapsone, doripenem, ganciclovir, heparin, certain antibiotics such as cephalosporins/penicillins/beta lactams/fosfomycin/nitrofurantoin).
Aspirin and other salicylate-type medicines can prevent probenecid from being fully effective. Many nonprescription products contain aspirin. Consult your pharmacist before using nonprescription medicines if you are uncertain whether they contain aspirin. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Ask your doctor or pharmacist for more details.
Alcohol can decrease this drug's effectiveness. Limit alcohol while taking this medication.
This medication may interfere with certain laboratory tests (including urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.